Genetic analysis and clinical application in polygenic diseases
نویسندگان
چکیده
منابع مشابه
Genetic bases for common polygenic diseases.
The present group of articles on the genetic basis of common diseases inaugurates a new policy on the part of the editors of the Proceedings. The editors plan to present a series of written minisymposia on dynamic and emerging areas of research of interest to broad groups of readers. We will solicit and present groups of interrelated articles by leading authorities and contributors describing t...
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Progress in molecular biology has opened the way to identifying genes involved in predisposition to multigene diseases. The two methods currently used for this purpose--analysis of candidate genes and systematic genomic screening--have given interesting but only very partial results. The problem is complicated by the large number of genes involved, their low penetrance, and linkage disequilibrium.
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15 صفحه اولGenetic drift and polygenic inheritance.
The interaction of random gene drift and selection was studied by computer simulation for two quantitative traits, which were considered to approximate stature and skin color dlfferences in human populations. The expected effects of gene drift, fixation of alleles and reduction of genotypic and phenotypic variances, were found in the simulation. Stabilizing selection, which seems to be the type...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 1999
ISSN: 0048-0444,1884-0108
DOI: 10.1272/jnms.66.308